Large-Scale Functional Analysis of CRP-Mediated Feed-Forward Loops
نویسندگان
چکیده
منابع مشابه
On the functional properties of microRNA-mediated feed forward loops
Motivation: Recent studies of genomic-scale regulatory networks suggested that a feed-forward loop (FFL) circuitry is a key component of many such networks. This led to a study of the functional properties of different FFL types, where the regulatory elements are transcription factors. Results: Here we investigate these properties when the mediating regulatory element of the loop is a microRNA....
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Given the important role of microRNAs (miRNAs) in genome-wide regulation of gene expression, increasing interest is devoted to mixed transcriptional and post-transcriptional regulatory networks analyzing the combinatorial effect of transcription factors (TFs) and miRNAs on target genes. In particular, miRNAs are known to be involved in feed-forward loops (FFLs), where a TF regulates a miRNA and...
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A prominent feature of gene transcription regulatory networks is the presence in large numbers of motifs, i.e., patterns of interconnection, in the networks. One such motif is the feed forward loop (FFL) consisting of three genes X, Y and Z. The protein product x of X controls the synthesis of protein product y of Y. Proteins x and y jointly regulate the synthesis of z proteins from the gene Z....
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BACKGROUND The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level. METHODOLOGY/PRINCIPAL FINDINGS Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcriptio...
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Even for models of very simple networks, like those in Chapters 2 and 3, describing the system requires many parameters. These parameters are often unknown or uncertain. Consequently, predicting the response of a gene circuit may require infering gene circuit function from data on circuit structure alone. By using the feed-forward loop as a model system, this chapter introduces a technique for ...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2018
ISSN: 1422-0067
DOI: 10.3390/ijms19082335